VisionArray ^® Chip for Genotyping of Pathogenic FUNGI

Fungal pathogens and infections are an increasing global public health concern. Recent assessments suggest that over a billion people are affected by fungal infections and more than 150 million people have serious fungal diseases, which have a major impact on their lives or are fatal. Mortality associated with fungal disease at >1.6 million per year is similar to that of tuberculosis. People most at risk are those with underlying health problems or a weakened immune system, such as chronic lung disease, prior tuberculosis, HIV, cancer, and diabetes mellitus. Early accurate diagnosis allows prompt antifungal therapy. However, this is often delayed or unavailable leading to death or serious chronic illness. The most frequently encountered pathogens are Aspergillus, Candida, Cryptococcus species, and Pneumocystis jirovecii, which are responsible for the majority cases of serious fungal disease. The diagnosis of invasive fungal infections is often challenging because of e.g. limited access to quality diagnostic tests. Direct microscopic examination of clinical samples may provide a tentative diagnosis, but this is often difficult to confirm by culture because of the presence of atypical fungal elements or sparse fungal populations. The VisionArray® Fungi Chip 1.0 is intended be used for the qualitative detection and genotyping of 30 clinically relevant fungi genotypes.

VisionArray ® FUNGI Chip 1.0

Chip Description

The VisionArray® FUNGI Chip 1.0 is intended to be used for the qualitative detection and genotyping of PCR-amplificates of 30 clinically relevant fungi genotypes that have been produced with the help of the VisionArray® FUNGI PreCise Master Mix 1.0 (Prod. No. ES-0009-50) from formalin-fixed, paraffin-embedded specimens. The chip is intended to be used in combination with a VisionArray® Software.