ZytoLight ® SPEC FOXO1/PAX3 TriCheckTM Probe

The ZytoLight ® SPEC FOXO1/PAX3 TriCheckTM Probe is designed to detect translocations involving the FOXO1 (a.k.a. FKHR) gene and the PAX3 gene.

Alveolar rhabdomyosarcoma (ARMS) is characterized by two tumor-specific translocations:

  • t(2;13)(q36;q14.1) involving FOXO1 and PAX3
  • t(1;13)(p36.1;q14.1) involving FOXO1 and PAX7

PAX7-FOXO1 is less common but is associated with a better prognosis than PAX3-FOXO1 fusion. The translocations and their fusion genes represent highly specific genetic markers useful in the diagnosis and prognosis of ARMS.

Probe Maps


Ordering Information

Prod. No.:Tests¹ (Volume):Registration Status²:
5 (50 µl)

Download Information


1 Using 10 μl probe solution per test.
2 In vitro diagnostic medical device according to EU directive 98/79/EC. 
CE IVD only available in certain countries. All other countries research use only! 
Please contact your local dealer for more information.

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