ZytoLight ® SPEC CBFB Dual Color Break Apart Probe

The ZytoLight ® SPEC CBFB Dual Color Break Apart Probe is designed to detect rearrangements involving the CBFB (core-binding factor beta, a.k.a. PEBP2B) gene. The chromosomal aberrations inv(16)(p13.1q22.1) and the related translocation t(16;16)(p13.1;q22.1), which have been detected in about 10% of patients with AML, lead to the fusion of the CBFB gene with the MYH11 gene. AML patients with these genetic rearrangements have a favorable prognosis. Inv(16) may sometimes be difficult to identify using conventional cytogenetic analysis. Accordingly, FISH proved to be a reliable method overcoming this problem and might consequently be a helpful tool to predict the prognosis of AML patients.

Probe Maps


Ordering Information

Prod. No.:Tests¹ (Volume):Registration Status²:
5 (50 μl)

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1 Using 10 μl probe solution per test.
2 In vitro diagnostic medical device according to EU directive 98/79/EC. 
CE IVD only available in certain countries. All other countries research use only! 
Please contact your local dealer for more information.

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