ZytoLight ® SPEC IRF4,DUSP22 Dual Color Break Apart Probe
The ZytoLight SPEC IRF4,DUSP22 Dual Color Break Apart Probe is designed to detect translocations involving the DUSP22 and IRF4 genes. Rearrangements of the IRF4/DUSP22 chromosomal region have been detected in various B-cell and T-cell lymphomas.
Large B-cell lymphoma (LBCL) with IRF4 rearrangement is considered a distinct new provisional entity. Most cases have IG/IRF4 fusions and have a favorable prognosis. Moreover, IRF4 translocation has a high specificity for cutaneous cutaneous anaplastic large cell lymphoma (ALCL) supporting the clinical utility of FISH for IRF4 in the differential diagnosis of T-cell lymphoproliferative disorders.
|Prod. No.:||Tests¹ (Volume):||Intended Use²:|
|1||Using 10 μl probe solution per test.|
|2||CE IVD only available in certain countries. All other countries research use only!
Please contact your local dealer for more information.