ZytoLight ® SPEC MAF/IGH Dual Color Dual Fusion Probe

The ZytoLight ® SPEC MAF/IGH Dual Color Dual Fusion Probe is designed to detect the translocations affecting the MAF gene in the chromosomal region 16q23.2 and the IGH locus in 14q32.33. The translocation t(14;16)(q32.3;q23) is frequently found in multiple myeloma (MM).

Five recurrent primary translocations involving the immunoglobulin heavy chain (IGH) locus have been identified; they include t(11;14)(q13.3;q32.3), t(6;14)(p21.1;q32.3), t(4;14)(p16.3;q32.3), t(14;16)(q32.3;q23), and t(14;20)(q32.3;q12), which involve the genes CCND1, CCND3, FGFR3 and NSD2, MAF, and MAFB, respectively. All of these translocations lead to the dysregulation and overexpression of the target genes as a consequence of their juxtaposition to regulatory sequences of the IGH locus.

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Prod. No.:Tests¹ (Volume):Registration Status²:
5 (50 µl)

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1 Using 10 μl probe solution per test.
2 In vitro diagnostic medical device according to EU directive 98/79/EC. 
CE IVD only available in certain countries. All other countries research use only! 
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